TRPC5 regulates the HIF-1α expression and its nuclear translocation in breast cancer cells (360), TRPC6 controls the hydroxylation and stability of HIF-1α in glioma (361), TRPM8 promotes HIF-1α levels by suppressing RAK1-mediated HIF-1α ubiquitination in prostate cancer (362), and TRPM2 increases HIF-1α levels by increasing transcription and decreasing degradation in neuroblastoma (363). This evidence concerns the gene HIF1A and Familial prostate cancer.