For differentiating sepsis from non-sepsis in ICU patients, IL-8, ACSL4, GPX4, CRP, PCT, NEU%, IL-6, and PTGS2(p-value =0.007) exhibited significant diagnostic value (all p-value <0.00001) (Figures 5C, D; Supplementary Figure 4B). The gene discussed is PTGS2; the disease is Sepsis.