MAPK1 and asthma: To verify whether circ-0001454 regulates cbl-b, EGFR, AKT1, and MAPK1 by targeting miR-770-5p, we designed the following experiments based on existing research:Research has demonstrated that in an OVA-induced asthma mouse model, the use of EGFR or Src inhibitors can significantly improve peribronchial inflammation, airway remodeling, and airway hyperreactivity (El-Hashim et al., 2017).