AKT1 and hypertensive disorder: Lu et al. (2024) found that the pathogenesis of hypertension and diabetic nephropathy comorbidities was related to Blautia and bile acid metabolites through multi-omics methods (Lu et al., 2024). Based on metabolomics and gut microbiota analysis, Bokhogainsam improved diabetic nephropathy by targeting phospholithin 3-kinase/protein kinase B (PI3K/Akt) and MAPK related proteins (Meng et al., 2020).