PEG-PC7A facilitates pH-responsive drug release, ensuring site-specific activation within the tumor microenvironment while regulating immune responses through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway (Li et al., 2024; Wang et al., 2021; Li Y. et al., 2023). Here, CGAS is linked to neoplasm.