AOPEP and familial hypercholesterolemia: mRNA: messenger ribonucleic acid; ApoB: apolipoprotein B; Apo(a): apolipoprotein A; ANGPTL3: angiopoietin-like protein 3; Lp(a): lipoprotein(a); HoFH: homozygous familial hypercholesterolemia; GaINAc: N-acetylgalactosamine; ASO: antisense oligonucleotide; PCSK9: proprotein convertase subtilisin/kexin type 9; LDL-C: low-density lipoprotein-cholesterol.