APOB and familial hypercholesterolemia: LDL-C: low-density lipoprotein-cholesterol; sd-LDL-C: small dense low-density lipoprotein-cholesterol; HDL-C: high-density lipoprotein-cholesterol; TG: triglycerides; ANGPTL3: angiopoietin-like protein 3; HoFH: homozygous familial hypercholesterolemia; ApoB: apolipoprotein B; LFTs: liver function tests; CVD: cardiovascular diseases.