ASOs: antisense oligonucleotides; LDL-C: low-density lipoprotein-cholesterol; HoFH: homozygous familial hypercholesterolemia; ANGPTL3: angiopoietin-like protein 3; PCSK9: proprotein convertase subtilisin/kexin type; LFTs: liver function tests. This evidence concerns the gene ANGPTL3 and homozygous familial hypercholesterolemia.