PPAR: peroxisome proliferator receptor; LDL: low-density lipoprotein-cholesterol; CVD: cardiovascular disease; TG: triglyceride; TCA: taurocholic acid; CYP2C8: cytochrome P450, family 2, subfamily C, polypeptide 8; OATP1Bi: organic anion transporting polypeptide 1B1; LPC: lysophosphatidylcholine; INR: international normalized ratio. Here, CYP2C8 is linked to cardiovascular disorder.