Positive high variant apolipoprotein L1 (APOL1) status confers higher odds for the development of genetic FSGS [2]. Podocytopathy associated with two high variant APOL1 alleles is associated with an earlier age of onset of FSGS and often leads to rapid progression to end-stage renal disease (ESRD) [3]. Here, APOL1 is linked to stage 5 chronic kidney disease.