Positive high variant apolipoprotein L1 (APOL1) status confers higher odds for the development of genetic FSGS [2]. Podocytopathy associated with two high variant APOL1 alleles is associated with an earlier age of onset of FSGS and often leads to rapid progression to end-stage renal disease (ESRD) [3]. The gene discussed is APOL1; the disease is chronic kidney disease.