CD8A and neoplasm: Phospholipid peroxidation disrupts protein–lipid interactions, alters theactivity of membrane-bound enzymes, and affects membrane permeability.Continuous, intensive oxidation of membrane phospholipid PUFAs induces plasmamembrane rupture and cell contents leakage into the intercellular environment.DAMPs in the tumor microenvironment (they may be divided into two subgroups,adjuvant and antigen) promote enhanced tumor infiltration by CD8+ Tcells, maturation of dendritic cells, and increased phagocytic activity bymacrophages [22, 23].