INS and Insulin resistance: Prior studies suggest that increasing social activities may counteract insulin resistance through complex interactions among various organs (46), Similarly, a study of 88,000 adults born before and after the Chinese Great Famine found that, after correcting for age imbalance, fetal exposure to famine could lead to permanent changes in the function and number of pancreatic ββ-cells and the tissue’s sensitivity to insulin (47), thereby indirectly improving metabolic function.