C: Left ventricular hypertrophy, EF < 50%, moderate-to-severe diastolic dysfunction, elevated BNP, carotid atheromasiaK: eGFR between 30 and 45 ml/min/1.73 m2, fast progressor (eGFR decline >7–8 ml/min/year), nephropathy diagnosisM: Retinopathy, microangiopathy, ulceration, inadequate glycemic control, UACR >300 mg/g. The gene discussed is NPPB; the disease is Nephropathy.