THBS2 and obesity due to melanocortin 4 receptor deficiency: In a study, liver histological assessments were performed on 252 patients [median age: 30.0, interquartile range (IQR): 25.0–37.0, 42.1% men, median BMI: 38.2, IQR: 33.4–44.5 kg/m2] with obesity, the result of the liver histological assessments was compared with the liver and blood levels of thrombospondin-2 (TSP2), and it was observed that TSP2 hepatic and blood serum expressions were elevated in patients with metabolic syndrome and steatohepatitis (85).