Analyzing the results using the high cut-off values of FIB-4 score by logistic regression analysis, AF is independently associated with advanced liver fibrosis (OR: 3.84, 95% CI: 1.29–11.43, p = 0.016) after sequential adjustment for gender, presence of diabetes, hypertension, obesity, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, albumin, gamma-glutamyl transferase and high-sensitivity C-reactive protein. This evidence concerns the gene ALB and Hepatic fibrosis.