For instance, it has been shown that exosomes from IL‐1β stimulated macrophages are enriched with miR‐146a, which reduces myocardial injury by inhibiting inflammatory responses and improving mitochondrial function through the MAPK4/DRP1 signalling pathway, accompanied by decreased serum myocardial enzymes and oxidative stress, thereby relieving myocardial injury during sepsis [89]. This evidence concerns the gene IL1B and Sepsis.