IL1B and Sepsis: In mice with sepsis‐induced myocardial dysfunction, oxidative stress increases the level of exosomal TXNIP‐NLRP3 complex derived from monocytes, which can be transported into the resident heart macrophages, where it activates caspase‐1 and cleaves inactive IL‐1β and IL‐18, thereby exacerbating cardiovascular inflammation [87].