When exosomal HSPA12B from endothelial cells is uptaken by LPS‐stimulated macrophages, HSPA12B reduces the production of TNF‐α and IL‐1β but increases the IL‐10 levels via downregulating NF‐κB activation and nuclear translocation, thus decreasing macrophage‐mediated pro‐inflammatory responses and sepsis‐induced cardiac injury and mortality [85]. Here, HSPA12B is linked to Sepsis.