The positive correlation between IGFBP‐2 and MAS‐1 expression is noteworthy, as higher IGFBP‐2 has been correlated with increased all‐cause mortality risk in multiple human aging cohorts (Hu et al. 2009; van den Beld et al. 2012; van den Beld et al. 2019) and predicts an increased rate of incident AD and dementia (McGrath et al. 2019; Quesnel et al. 2022; Quesnel et al. 2024). The gene discussed is IGFBP2; the disease is Alzheimer disease.