It is also worth mentioning that the late-onset AD risk factor phosphatidylinositol binding clathrin assembly protein (PICALM) has been identified as a functional, and perhaps physical, link between LRP1 and P-gp, guiding both proteins through the endocytotic pathway in cerebrovascular endothelium (Storck et al., 2018). Here, LRP1 is linked to Alzheimer disease.