UGT2B28 and obesity due to melanocortin 4 receptor deficiency: For UGT2B28 KO males, characterized by globally lower levels of phospholipids, higher levels of 1-stearoyl-glycerophosphoethanolamine and 1-palmitoyl-2-stearoyl-glycerophosphatidylcholine were strongly linked to a lower risk of obesity and hypertension, whereas taurine, which was lower in males, was associated with a reduced risk of arthritis (Supplementary Fig. 6F).