KRT7 and neoplasm: EMA: Revealed positive membrane staining of tumor cells, CK- 7: Revealed negative cytoplasmic staining of tumor cells, CK- 19: Revealed positive cytoplasmic staining tumor cells, Heppar- 1: Revealed positive granular cytoplasmic staining of tumor cells, CD- 15: Revealed negative membrane staining of tumor cells, which gave the diagnosis of hepatocellular carcinoma that metastasized to the skull and appeared as primary symptom.