In contrast, both conditional KO and gene restoration in Asic4−/− studies discounted a role for hippocampal ASIC4 in innate anxiety, although the hippocampus plays an important role in anxiety [32] and fear memory [14, 31], and fear extinction requires ASIC1a-dependent regulation of the ventral hippocampus [36]. The gene discussed is ASIC4; the disease is Anxiety.