CXCL8 and neoplasm: IL-6 significantly elevates in GC patients and is positively correlated with C-reactive protein (CRP) level, tumor size, stage [97], invasion, lymph node, and hepatic metastasis [98], and survival time [99]. Il-8 is the most selective and consistent gene in HAG patients [100], and it is the most up-regulated gene according to whole-genome profiling of Helicobacter-exposed gastric epithelial cells [101].