Juglans regia L. treatment alleviated pathological damage to the gastric mucosa, including inflammation, ulcers, atrophy, and adenoma, and ameliorated NF-κB, p-p65, STAT3, pSTAT3, IL-6, COX-2/COX-1, PGE2, c-Myc, and Ki-67, whereas increasing the levels of the defensive protein 15-PGDH and the JAK/STAT regulator suppressor of cytokine signaling 1 (SOCS-1) [17]. The gene discussed is HPGD; the disease is ulcer disease.