Helicobacter-induced and high salt diet WT mice were sacrificed after 24 weeks (a time to establish a CAG model) and 36 weeks (a time to establish a GC model), respectively, after which NF-κB (p-p65) and STAT3 (pSTAT3) were activated and inflammatory biomarkers IL-6, COX-2, and PGE2 were overexpressed. This evidence concerns the gene PTGS2 and gastric cancer.