Juglans regia L. obviously improved HAG condition (edema, erythema, inflammation, ulcer) and subsequent disease deterioration (ulcer, atrophy, tumor, pale and thin mucosa), which accompanied lower production of IL-6, COX-2/COX-1, PGE2, c-Fos, c-Jun, c-Myc, p-p65, and pSTAT3. Here, JUN is linked to ulcer disease.