STAT3 activation and subsequent tumor development do not occur without the Glycoprotein 130 (gp130) receptor, which is a signaling element of the IL-6R‒gp130 complex, and the IL-6 family member IL-11 is a promotion element of GC by activating STAT3 to overexpress proliferative genes in mice [146, 147]. The gene discussed is IL6R; the disease is neoplasm.