IL1B and gastric adenocarcinoma: In addition, the CagA protein, transcribed by the CagA gene, which includes two critical motifs, EPIYA and CRPIA, accounts for the high expression of proinflammatory cytokines (IFN-γ, IL-1β [90], and IL-8 [91]), DNA damage [92], gastric epithelial cell apoptosis, and gastric adenocarcinoma.