Specific mutations of Parkin and PINK1 (Sect. "Dysfunctional autophagy, mitophagy, remodeling of the mitochondrial membranes, and budding of mitochondrial-derived vesicles") are associated with Parkinson’s disease (PD), with the serum of these patients containing high levels of pro-inflammatory cytokines [99, 326, 327]. The gene discussed is PRKN; the disease is Parkinson disease.