CGAS and systemic lupus erythematosus: Multiple and amplified mtDNA signals leading to IFN-I production have been shown in SLE (an autoimmune disease characterized by the production of antibodies that react against self-antigen), including activation of cGAS by RBCs retaining mitochondria, unconventional production of IL-1β by monocytes [158] and NETs enriched of ox-mtDNA [142].