EBF3 and breast cancer: To confirm the hypothesis that SNORA47 might influence the translocation of RPL11 within the nucleolus and nucleoplasm through its interaction with EBF3, thereby promoting the retention of a greater amount of RPL11 in the nucleolus, we performed Western blotting analysis after a nucleolus-nucleoplasm separation assay and revealed increased expression of RPL11 within the nucleolus in breast cancer cells overexpressing SNORA47 than in controls, while conversely, SNORA47 expression was elevated within the nucleoplasm in breast cancer cells with silenced SNORA47 (Fig. 4A-B; Fig. S4A-B).