To determine whether SNORA47 mediates the different expression profiles of RPL11 in the nucleolus and nucleoplasm via EBF3, we induced knockdown of EBF3 in breast cancer cells that overexpressed SNORA47 and observed that the alterations in the expression levels of RPL11 within the nucleolus and nucleoplasm were abrogated (Fig. 4C-D; Fig. S4C-D). This evidence concerns the gene EBF3 and breast carcinoma.