MDM2 and hepatocellular carcinoma: For example, SNORA18L5 was able to promote ribosomal biosynthesis, increase the maturation of rRNA size subunits, inhibit the entry of RPL5/RPL11 ribosomal proteins into the nucleoplasm to bind to MDM2, and promote the ubiquitylation and degradation of the target P53 to exert the oncogenic effects of snoRNAs in hepatocellular carcinoma cells (Cao et al. 2018).