The polyphenol phloretin (Ph), isolated from apples, significantly antagonizes GLUT1 in daunorubicin-resistant breast cancer cells and CRC cells, markedly inhibiting glucose uptake and inducing apoptosis in daunorubicin-resistant cells, thereby enhancing chemotherapeutic efficacy (Cao et al. 2007). This evidence concerns the gene SLC2A1 and breast carcinoma.