Additionally, protein arginine methyltransferase 6 (PRMT6) mediated methylation at R9 and R372 of ENO1 promotes the formation of its active form and facilitates the binding of 2-phospho-glycerate to ENO1, thereby upregulating glycolysis and DDP resistance in lung cancer (Sun et al. 2023a). Here, PRMT6 is linked to lung cancer.