In CRC, the immunoregulatory protein B7 homolog 3 (B7-H3) promotes the expression of HK2 through the phosphorylation of signal transducer and activator of transcription 3 (STAT3), thereby conferring resistance to 5-FU and oxaliplatin (L-OHP) (Shi et al. 2019). This evidence concerns the gene CD276 and colorectal carcinoma.