In hepatocellular carcinoma (HCC) cells, the expression of GLUT1 is upregulated by spalt-like transcription factor 4 (SALL4) in a heterochromatin protein 1α (HP1α)-dependent manner, which confers doxorubicin (DOX) resistance to HCC cells by enhancing DNA damage responses (Kim et al. 2017). The gene discussed is SALL4; the disease is hepatocellular carcinoma.