LDHA and colorectal carcinoma: Methyltransferase 3 (METTL3) and insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) mediate m6 A modification by activating the transcription and translation of LDHA, which increases LDHA-mediated chemoresistance in CRC (Zhang et al. 2022; Jiang et al. 2022b).