It has been found that the IgA immune complex-FcαRI interaction may trigger inflammatory reactions by neutrophils and macrophages in the joints of patients with RA, and it has been shown that blocking the interaction between FcαRI and IgA RF in macrophages can lead to a local decrease in the level of the proinflammatory cytokine TNF-α (Anquetil et al. 2015). Here, CD79A is linked to rheumatoid arthritis.