Considered across all experiments, the general observation of a defect in hedonic reactions to sucrose in Cacna1c+/− rats is not only consistent with the fact that variation in this VGCC‐encoding gene is associated with risk for multiple psychiatric disorders where anhedonia is a key symptom, but also consistent with the specific impacts of variation in CACNA1C in humans on reward processing. The gene discussed is CACNA1C; the disease is psychiatric disorder.