PDC and anemia: It is likely that these, at least in part,reflect dynamic conformational changes during 2OG oxygenase catalysis,including those relating to the dimeric nature of BBOX and the associatedcooperative nature of cosubstrate/substrate binding to BBOX.39,69 We envisage that similar strategies may be employed to identifyselective active-site-binding inhibitors of other 2OG oxygenases.In addition, the inhibition studies described will likely inform thedesign of more efficient and selective PHD inhibitors based on theDesidustat scaffold for anemia treatment.