It is likely that these, at least in part,reflect dynamic conformational changes during 2OG oxygenase catalysis,including those relating to the dimeric nature of BBOX and the associatedcooperative nature of cosubstrate/substrate binding to BBOX.39,69 We envisage that similar strategies may be employed to identifyselective active-site-binding inhibitors of other 2OG oxygenases.In addition, the inhibition studies described will likely inform thedesign of more efficient and selective PHD inhibitors based on theDesidustat scaffold for anemia treatment. This evidence concerns the gene PDC and anemia (phenotype).