BACH1 stability is sensitive to heme or hemin, which are essential for E3 ubiquitin ligases, including HOIL-1 and FBXO22, mediated BACH1 degradation via proteasome in lung cancer cells (Lignitto et al, 2019; Suzuki et al, 2004; Zenke-Kawasaki et al, 2007). The gene discussed is FBXO22; the disease is lung cancer.