CDKN2A and Miyoshi myopathy: MSC senescence is a feature of MM, with several studies reporting that MSCs from the BM of MM patients display higher levels of cellular senescence compared with those from healthy donors, as demonstrated by increased β-gal positivity, flattened and enlarged cell morphology, reduced proliferative and osteogenic differentiation potential and upregulated expression of senescence-associated genes including CDKN2A (p16/p14) and secretion of SASP factors [11–18].