CDKN2A and cancer: Furthermore, expression of ageing-related replicative senescence marker CDKN2A, as assessed by qRT-PCR, was significantly increased 1.8-fold in MSCs from MGUS and MM patients, compared with younger non-cancer controls (p = 0.02 and p = 0.006, respectively, Kruskal-Wallis test with Dunn’s post-test; Fig. 1F).