PLA2G6 and neurodegeneration with brain iron accumulation 2A: Alternatively, idiopathic bilateral brachymetarsia may have occurred independently and coincided with PLAN owing to a homozygous biallelic variant in strong linkage disequilibrium with the identified variant of PLA2G6. Whole-exome sequence data were analyzed to search for such variants; however, numerous nonsynonymous homozygous variants were identified near the PLA2G6 locus, making it challenging to draw definitive conclusions.