Of the 62 pQTLs that have not been previously reported, 4 are cis-pQTLs, while 58 are in trans. The 4 newly-reported cis-pQTLs include the Islet Cell Autoantigen 1 (ICA1; pQTL lead SNP: rs7785777), a potential minor T1D autoantigen, AKT Serine/Threonine Kinase 2 (AKT2; pQTL lead SNP: rs4530264), which is involved in insulin signalling8, HRas Proto-Oncogene, GTPase (HRAS; pQTL lead SNP: rs2061586) and Mitochondrial Ribosomal Protein L28 (MRPL28; pQTL lead SNP: rs3859153). This evidence concerns the gene INS and type 1 diabetes mellitus.