HTT and Huntington disease: Similar to differentiated neurons from HD patient-derived iPSCs, larval segmental neurons from larvae expressing pathogenic HTT contained axonal blockages that stained with HTT and synaptic proteins [33], show disrupted transport of RAB proteins [32, 34], accumulation of HTT/polyQ aggregates and cell death [30, 79, 80] indicating that both human HD iNeurons and Drosophila neurons expressing pathogenic HTT show similar dysfunctions.