HSP90AA1 and cervical carcinoma: This indicated that HSP90 knockdown enhanced the radiosensitivity of HeLa cells, which could be restored by overexpressing dCK (Fig. 6F, G).To further confirm the role of HSP90 in vivo, we constructed a cervical cancer model in nude mice, which showed that the HSP90 inhibitor 17-AAG was able to reduce the tumour volume and tumour after radiation without any significant effect on the body weight of the mice(Fig. 6H–L), which further demonstrated the role of 17-AAG as a radiosensitizing drug for cervical cancer.