RNA sequencing studies demonstrated that IL18-overexpressing B16-F10 melanomas are enriched in transcripts associated with NK cell activity as compared to their IL18D69A-overexpressing counterparts, notably transcripts coding for interferon-stimulated genes (ISGs), an effect that was linked to increased activating phosphorylation of signal transducer and activator of transcription 1 (STAT1). The gene discussed is STAT1; the disease is melanoma.