For example, of the 21 genes enriched from endometriosis in ‘signalling by reception tyrosine kinase’, 8 are shared with osteoarthritis, including NCF4, LAMB2, RHOA, MST1, MST1R, MAPKAPK3, DOCK3, and PTK2B, and 3 are shared with multiple sclerosis, including ITGB3, PRKCA, and MMP9 (Supplementary Fig. S10a). This evidence concerns the gene PRKCA and osteoarthritis.