MAPT and Alzheimer disease: Previous studies have shown that chronic administration of 670nm PBM induces synaptic resilience to Aβ oligomers and reduces Aβ deposition in the amyloidogenic Tg2576 mouse model [17], and reduces oligomeric tau, and increases markers of autophagy at the synapses of 12-month-old 3xTg-AD mice [18].