Additionally, 13-HODE as a product of lipoxygenase may be connected to the Th2 type of response as it was previously seen in asthma when lipoxygenases were activated by the asthmatic IL4/IL-13 type of immune response with elevated production of 12/15-lipoxygenase products such as 13-HODE in airway epithelial cells [39, 40]. The gene discussed is IL4; the disease is asthma.