Apert syndrome (AS) is thought to be caused by c.755 C > G (p.Ser252 Trp) Ser252 Trp variant in the FGFR2 gene, which results in a malformed skull and delayed skeletal development due to early union of the cleft palate and craniofacial sutures [16, 34]. This evidence concerns the gene FGFR2 and Apert syndrome.