Several genetic syndromes present with craniosynostosis, a gain of function variants of the FGFR2 gene, mainly in the third Ig-like domain and adjacent linker regions, leading to multiple types of autosomal-dominant craniosynostoses, such as Apert syndrome, Crouzon syndrome, Pfeiffer syndrome, and Beare-Stevenson cutis gyrata syndrome [24]. The gene discussed is FGFR2; the disease is Crouzon disease.