Pathogenic variants in the FGFR2 gene, particularly the Ser252 Trp and Pro253 Arg variants, play an important role in bone growth disruption resulting in craniosynostosis and syndactyly the key diagnostic indicators of AS that differentiate it from other craniosynostosis syndromes [18, 25]. Here, FGFR2 is linked to syndromic craniosynostosis.