ERBB2 and neoplasm: Unique to BCBM, our data supports evaluation of BCBM receptor status, suggests an important role for anti-HER2 in contributing to surgical bed and intracranial control, and supports current call for research in brain metastasis to further explore unique findings associated with tumor histology and biology and treatment measures (such systemic therapy and radiation) to prevent CNS spread such as leptomeningeal disease [18].