The biology of the primary breast cancer was significant, local control was significantly better in HER2 positive compared to HER2 negative (50% vs 16.1%, P = 0.015) and luminal B compare to non-luminal B (20% vs. 5%, p = 0.049) achieved local control cavity recurrence free survival time according to different histology is shown on Kaplan –Meier curves in Fig. 1. The gene discussed is ERBB2; the disease is breast cancer.