VEGFA and neoplasm: In line with the findings of Li et al. [36], they demonstrated that radiological response (≥ 20% volume decrease at 6 months) but not hearing response was associated with higher pre-treatment tumour Ktrans and reductions in both plasma free VEGF/VEGF-D and the Ang2/Tie- 2 axis, as measured through soluble Angiopoietin- 1 receptor (sTie- 2) [9].