Compared to normal rats, IL- 6, endocan, ET- 1, and TGF-β1 levels were significantly elevated in response to HTN induced by DOCA (174.3 ± 3.05 pg/ml, 403.8 ± 3 ng/ml, 8.04 ± 0.06 pg/ml, and 222.69 ± 0.57 pg/ml vs. 66.6 ± 3.03 pg/ml, 200.4 ± 2.37 ng/ml, 4.07 ± 0.05 pg/ml, and 40.13 ± 1.05 pg/ml, respectively, p < 0.001). The gene discussed is ESM1; the disease is hypertensive disorder.