PTPN22 and type 1 diabetes mellitus: AnotherwGRS, incorporating HLA DR/DQ SNPs and 40 non-HLA SNPs, showed highefficacy in detecting pre-symptomatic or symptomatic T1DM patients, with an AUC of0.68 (0.63 - 0.73) (Bonifacio et al. 2018).Additionally, Sharp et al. (Sharp et al.,2019) demonstrated that a wGRS comprising 67 non-HLA SNPs (containing thers2476601/PTPN22 SNP) and 18 HLA DR-DQgenotypes, efficiently discriminated between T1DM patients and controls from theT1DGC Dataset (AUC = 0.92; P <0.0001) (Sharpet al. 2019).