MAFs of the HLA DR4/DQ8, DR3/DR4-DQ8 or DR3/DR(high-risk genotypes for T1DM), TYK2 rs230456,ERBB3 rs2292239, INS rs689,PTPN22 rs2476601, and CTLA4 rs231775 SNPs,along with their respective ORs, used to calculate the uGRS (MAFs) and wGRS(MAFs and ORs), are provided in Table 3.These SNPs were selected based on a candidate gene approach for inclusion in theGRS models. This evidence concerns the gene PTPN22 and type 1 diabetes mellitus.