Patients in this study were more likely to receive SAT if there were features present that have previously been associated with PJI treatment failure, such as older age, medical comorbidities, presentation with a sinus tract, and a higher baseline CRP (15, 16); however, SAT was still used in a significant minority of patients who would usually be considered to have curable infections, such as patients with early PJI treated with DAIR or those with chronic PJI treated with two-stage exchange. This evidence concerns the gene CRP and infection.