Additionally, a negative correlation between PIAS1 and γH2AX scores was observed in SPOP-WT PCa tissue groups (Supplemental Figure 3E), but not in SPOP-mutated PCa tissue groups (Figure 5G), suggesting that the role of PIAS1 in regulating genomic stability is associated with SPOP. The gene discussed is PIAS1; the disease is posterior cortical atrophy.