AR and posterior cortical atrophy: Given that genomic instability may improve the sensitivity of PCa cells to olaparib treatment, we constructed stable PCa cell lines, including 2 androgen receptor–negative (AR-negative) PCa cell lines (PC-3 and DU145) and 2 AR-postive (LNCaP and 22RV1) cell lines, carrying the SPOP-WT or SPOP mutants (SPOP-K101I and -F133L), respectively, to test this hypothesis.