SPOP and posterior cortical atrophy: Subsequently, DNA sequencing was performed to identify 6 PCa patients harboring SPOP genes (c.268C>G, L90V; c.302A>T, K101I; c.373G>T, F125V; c.385A>G, K129E; c.399C>G, F133L; and c.399C>A, F133L) with a mutation rate of approximately 12% (6 out of 50; Supplemental Figure 1C).