SPOP and posterior cortical atrophy: SPOP gene mutations occur in 10%–15% of PCa cases and are predominantly located within the substrate-binding MATH domain (8) (Supplemental Figure 1A; data from COMSIC, https://cancer.sanger.ac.uk/cosmic; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.186871DS1).