SPOP and posterior cortical atrophy: Based on the IC50 values obtained from Figure 1B, we assessed the apoptosis level of PCa cells PC-3 and DU145, as well as LNCaP cells, after 24 hours of treatment and found that PCa cells with SPOP knockdown exhibited increased apoptosis under olaparib treatment, whereas PCa cells carrying SPOP-K101I/F133L exhibited more pronounced apoptosis (Figure 1, C and D, and Supplemental Figure 1, D–F).