INS and Hyperglycemia: Moreover, this intervention reduced liver inflammation and alleviated early symptoms of fibrosis.184,185 Additionally, modification of Lactobacillus to secrete GLP-1 and induce insulin secretion has shown improvement in hyperglycemia symptoms in diabetic rat models.186 Tissue accumulation of Pyrroloquinoline quinone (PQQ) can prevent oxidative damage both locally within the liver and systemically throughout the body.