SNCA and Parkinson disease: Typically, Sporadic PD models use neurotoxins like 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), rotenone, and 6‐OHDA, while familial PD models overexpress wild type or mutated genes such as SNCA, LRRK2, Parkin, and PINK1 [18, 19, 20, 21].