Furthermore, studies have shown that in rats with post-traumatic stress disorder, NLRP3 inflammasome activation in the dorsal raphe nucleus impairs mitochondrial function by inhibiting ATP synthesis and increasing ROS production, while SA can effectively reverse the pathological progression of mitochondria [13].Our study demonstrated that SA reduced levels of phosphorylated AKT in renal tissues and renal tubular epithelial cells during IRI. Here, AKT1 is linked to post-traumatic stress disorder.