RHOA and cancer: Specifically, miR-143 targets KRAS (Kirsten rat sarcoma viral oncogene homolog), a pivotal player in cell signaling, while miR-145 directly regulates CDC42(Cell Division Cycle 42) and RhoA (Ras Homolog Family Member A), which are crucial for the cytoskeletal organization and invasive behavior in cancer cells (Liu et al., 2019; Zhang et al., 2021).