Similarly, determinants significantly affected CD4 cell count were baseline CD4 count, younger age, working functional status, time in treatment contributed [27], clinical stage, tuberculosis (TB) co-infection [28], hematocrit, platelet cell count, lymphocyte count, sex, adherence, [29], higher viral load [29], stavudine-based regimen, a low body weight, starting ART with a stavudine-based regimen [30], ownership of cell phone, marital status, residence area, level of disclosure of the disease to family members [31], baseline hemoglobin levels, and actively working patients [32]. This evidence concerns the gene CD4 and coinfection.