At the same time, there are four members of the FOXO family in mammals: FOXO1 (known as forkhead in rhabdomyosarcoma, FKHR), FOXO3 (also known as FOXO3a, or forkhead in rhabdomyosarcoma like protein 1, FKHRL1), FOXO4 (also known as the acute leukemia fusion gene located in chromosome X, AFX), and FOXO6 (Webb et al., 2016). Here, FOXO4 is linked to rhabdomyosarcoma.