AKT1 and cancer: The PI3K/AKT/mTOR pathway regulates cell survival, growth, and metabolism, and is abnormally activated or deregulated in most human cancers; it is associated with anti-apoptosis and pro-survival properties (Fattahi et al., 2020; Kang and Chau, 2020; Baghery Saghchy Khorasani et al., 2021).