Recently, Alsoudi et al. (2024) suggested that the sequence of treatment in combination therapy may impact patient outcomes in large-scale retrospective studies; they reported that patients treated with PRP prior to anti-VEGF injections had higher risks of vitreous hemorrhage, tractional retinal detachment, or progression to pars plana vitrectomy compared to those treated with anti-VEGF injections prior to PRP. The gene discussed is VEGFA; the disease is vitreous hemorrhage.