Although anti-VEGF administration prior to PPR could favor relief from ME, prompt recovery of visual acuity, and avoidance of ME severity induced by PRP, some practitioners choose to commence PRP prior to anti-VEGF for exuberant iris or angle new vessels in RVO or any imminent vitreous hemorrhage in severe PDR (Filho et al., 2011; Messias et al., 2012). This evidence concerns the gene VEGFA and vitreous hemorrhage.