CHUK and acute myeloid leukemia: PPI network analysis revealed that 13 APSRDEGs were interconnected, and nine hub genes were identified: CASP3, PTPRC, ELANE, HMOX1, CHUK, FLT1, JAK3, CTSL, and AURKA. GO and KEGG enrichment analyses indicated that these genes were significantly associated with key biological processes, cellular components, molecular functions, and pathways involved in AML.