The intersection of APSRGs and DEGs was visualized using a Venn diagram and yielded 20 APS-related differentially expressed genes (APSRDEGs): ALOX5, ALPL, FLT1, GABRG2, HMOX1, ILK, JAK3, PDE4A, PTPRC, and SLC9A1 (Figure 4B). Here, PDE4A is linked to autoimmune polyendocrinopathy.